BioMaths Colloquium Series - 2019/20
07 February 2020 - 3pm Zoology Museum
(Wallace Building, Singleton Campus)
Biomechanics and mechanobiology for bone tissue engineering in vitro
Dr Zhao Feihu
(College of Engineering, Swansea University)
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| image by Zhao Feihu |
Our BioMaths Colloquium Series resumes for the winter term with a seminar by Dr Zhao Feihu, from the Zienkiewicz Centre for Computational Engineering at Swansea University. Zhao is a Lecturer in Biomedical Engineering and joined Swansea University in 2019, from the Eindhoven University of Technology. Zhao's research interest are in mechano-biology, using computational and experimental approaches, such as in silico bone tissue engineering, effects of stretching and mechanical stimulation on the development and characteristics of cells, etc.
Abstract
Abstract
Mechanical stimulation can regulate cellular activities in vivo, e.g. differentiation, proliferation and extracellular matrix (ECM) production. In vivo evidence has shown that higher bone mineral density can be achieved under mechanical stimulation (mechanical strain and/or fluid induced wall shear stress). If mechanobiological findings can be translated to bone tissue engineering in vitro, we may accelerate osteogenesis and enhance mineralised bone tissue formation, which for example can be used for drug testing to treat osteoporosis. Therefore, we aimed to explore this possibility by applying different mechanical stimulations to the cells (stem cells and bone cells) using different bioreactor techniques. Furthermore, to refine the in vitro bone tissue engineering experiments and reduce trial-and-error experiments, we used in silico (computational) approaches to find the optimal cellular mechanical stimulation for bone tissue engineering, and predicted how mineralised bone tissue grew within biomaterial scaffolds under different mechanical stimulations.
The discussions will continue over tea and coffee after the seminar.
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